Webinar Title: Importance of Genetic Background on Mice and Rat Models
When: [New date] 20th September 2018, 16:00-17:00 GMT
Presenter: Professor Fernando Benavides
Synopsis: It is increasingly recognized that the genetic background (i.e., all genomic sequences other than the gene(s) of interest) can have profound influences on the phenotype of an animal model. It has been shown that mutations (spontaneous and induced), transgenes, and targeted alleles (knockouts and knockins) that are “moved” onto a different background can show a change in phenotype. In order to highlight the importance of this issue, a selection of recently published articles showing the influence of genetic background on different mouse and rat models will be presented, along with different ways to avoid or resolve these problems. Finally a summary of differences within classical substrains of mice, including the so-called “passenger mutations” will be discussed.
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